Precise control of plant stem cell activity through parallel regulatory inputs

Bennett, T., van den Toorn, A., Willemsen, V. and Scheres, Ben ORCID: https://orcid.org/0000-0001-5400-9578 2014. Precise control of plant stem cell activity through parallel regulatory inputs. Development 141 (21) , pp. 4055-4064. 10.1242/dev.110148

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Abstract

The regulation of columella stem cell activity in the Arabidopsis root cap by a nearby organizing centre, the quiescent centre, has been a key example of the stem cell niche paradigm in plants. Here, we investigate interactions between transcription factors that have been shown to regulate columella stem cells using a simple quantification method for stem cell activity in the root cap. Genetic and expression analyses reveal that the RETINOBLASTOMA-RELATED protein, the FEZ and SOMBRERO NAC-domain transcription factors, the ARF10 and ARF16 auxin response factors and the quiescent centre-expressed WOX5 homeodomain protein each provide independent inputs to regulate the number of columella stem cells. Given the tight control of columella development, we found that these inputs act in a surprisingly parallel manner. Nevertheless, important points of interaction exist; for example, we demonstrate the repression of SMB activity by non-autonomous action of WOX5. Our results suggest that the developmental progression of columella stem cells may be quantitatively regulated by several more broadly acting transcription factors rather than by a single intrinsic stem cell factor, which raises questions about the special nature of the stem cell state in plants.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	Company of Biologists
ISSN:	0950-1991
Last Modified:	27 Oct 2022 09:57
URI:	https://orca.cardiff.ac.uk/id/eprint/68318

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