Impairment of colour vision associated with amiodarone keratopathy

Duff, G. R. and Fraser, Alan Gordon 1987. Impairment of colour vision associated with amiodarone keratopathy. Acta Ophthalmologica 65 (1) , pp. 48-52. 10.1111/j.1755-3768.1987.tb08490.x

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Abstract

Objective changes in colour vision have not been demonstrated previously in patients on long-term amiodarone therapy, although the occurrence of blurring of vision and seeing coloured haloes around lights has been widely reported. In a masked study, colour vision was assessed in 15 patients who had been treated with amiodarone for 16-72 months. Subjects with extensive corneal microdeposits (Miller stage 3) had worse colour vision than subjects with mild or moderate corneal changes (Miller stages 1 and 2) (P = 0.02), and higher serum concentrations of the metabolite desethlyamiodarone (P = 0.008). The only subject with marked asymmetry of corneal changes had a long-standing unilateral ptosis, suggesting that exposure to light might influence the development of corneal changes.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > RE Ophthalmology R Medicine > RZ Other systems of medicine
Publisher:	Wiley-Blackwell
ISSN:	1755-375X
Last Modified:	04 Jun 2017 07:50
URI:	https://orca.cardiff.ac.uk/id/eprint/68514

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