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A possible drug interaction between rifampicin and enalapril

Kandiah, D., Penny, W. J., Fraser, Alan Gordon and Lewis, Malcolm John A possible drug interaction between rifampicin and enalapril. European Journal of Clinical Pharmacology 35 (4) , pp. 431-432. 10.1007/bf00561378

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When a 35-year-old man with essential hypertension was treated with antibiotics for brucellosis his blood pressure rose significantly. While all other treatment was kept constant rifampicin was discontinued. On rechallenge rifampicin did not alter serum concentrations of enalapril or the area under the curve (AUC) between 0 and 7 h, but it did reduce the AUC of the active metabolite enalaprilat by 31%. These observations suggest that there may be an interaction between rifampicin and enalapril, causing reduced hypotensive efficacy of enalapril. The mechanism of such an interaction merits further study, but it could be due to enhanced renal clearance of enalaprilat.

Item Type: Article
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RZ Other systems of medicine
Publisher: Springer Verlag
ISSN: 0031-6970
Last Modified: 04 Jun 2017 07:50

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