Borko, Lubomir, Bauerova-Hlinkova, Vladena, Zahradnikova, Alexandra, Kostan, Julius, Beck, Konrad ![]() ![]() |
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Official URL: http://dx.doi.org/10.1016/j.bpj.2013.11.661
Abstract
Human cardiac ryanodine receptor (hRyR2) is a channel mediating Ca2+ release from the sarcoplasmic reticulum during excitation-contraction coupling. The N-terminal (1-655) and central (2100-2500) regions of hRyR2 are thought to be involved in regulating channel gating. Mutations linked to several heart diseases are clustered within these two, as well as in the channel pore-containing C-terminal regions. High resolution structures of key regions involved in the regulation of RyR2 activity could further the understanding of the gating mechanism of hRyR2 and of its malfunction in disease.
Item Type: | Article |
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Date Type: | Published Online |
Status: | Published |
Schools: | Biosciences Dentistry |
Additional Information: | Pdf uploaded in accordance with publisher's policies at http://www.sherpa.ac.uk/romeo/issn/0006-3495/ (accessed 19.12.14). |
Publisher: | Biophysical Society |
ISSN: | 0006-3495 |
Last Modified: | 05 Jan 2024 08:14 |
URI: | https://orca.cardiff.ac.uk/id/eprint/68578 |
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