Molecular mechanisms of memory retrieval [review]

Szapiro, G., Galante, Mariana Julieta, Barros, Daniela M., Levi de Stein, Miguelina, Vianna, Monica R. M., Izquierdo, Luciana A., Izquierdo, Ivan and Medina, Jorge H. 2002. Molecular mechanisms of memory retrieval [review]. Neurochemical Research 27 (11) , pp. 1491-1498. 10.1023/A:1021648405461

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Abstract

Memory retrieval is a fundamental component or stage of memory processing. In fact, retrieval is the only possible measure of memory. The ability to recall past events is a major determinant of survival strategies in all species and is of paramount importance in determining our uniqueness as individuals. Most biological studies of memory using brain lesion and/or gene manipulation techniques cannot distinguish between effects on the molecular mechanisms of the encoding or consolidation of memories and those responsible for their retrieval from storage. Here we examine recent findings indicating the major molecular steps involved in memory retrieval in selected brain regions of the mammalian brain. Together the findings strongly suggest that memory formation and retrieval may share some molecular mechanisms in the hippocampus and that retrieval initiates extinction requiring activation of several signaling cascades and protein synthesis.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > RZ Other systems of medicine
Uncontrolled Keywords:	Animals,AvoidanceLearning,Hippocampus/physiology,Humans,Memory*,Neuronal Plasticity
Publisher:	Springer Verlag
ISSN:	0364-3190
Last Modified:	19 Mar 2016 23:52
URI:	https://orca.cardiff.ac.uk/id/eprint/69577

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