Ryanodine receptor dysfunction in arrhythmia and sudden cardiac death

George, Christopher H., Thomas, Nia Lowri ORCID: https://orcid.org/0000-0001-8822-8576 and Lai, Francis Anthony ORCID: https://orcid.org/0000-0003-2852-8547 2005. Ryanodine receptor dysfunction in arrhythmia and sudden cardiac death. Future Cardiology 1 (4) , pp. 531-541. 10.2217/14796678.1.4.531

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Abstract

Mutations in ryanodine receptor calcium ion-release channels (RyR2) have emerged as important causative players in exercise/stress-induced ventricular arrhythmia leading to sudden cardiac death (SCD). Thus, RyR2 represents an attractive therapeutic target, and a detailed understanding of the mechanistic basis of RyR2 dysfunction at the molecular, cellular and organ level is essential for the development of novel, more effective therapeutic approaches to prevent arrhythmia and SCD. Such advances will translate into a tremendous improvement in the survival and quality of life of SCD-susceptible individuals. In this review, the authors consider how recent knowledge gained from mutation identification, phenotypic manifestation and functional evaluation of RyR2 mutants, are being used to develop novel therapeutic strategies in RyR2-dependent arrhythmia.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Future Medicine
ISSN:	1479-6678
Last Modified:	27 Oct 2022 10:20
URI:	https://orca.cardiff.ac.uk/id/eprint/69753

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