Attenuated adenomatous polyposis coli - The role of ascertainment bias through failure to dye-spray at colonoscopy

Wallace, Marina, Frayling, Ian, Clark, Susan, Neale, Kay and Phillips, Robin K. S. 1999. Attenuated adenomatous polyposis coli - The role of ascertainment bias through failure to dye-spray at colonoscopy. Diseases of the Colon & Rectum 42 (8) , pp. 1078-1080. 10.1007/BF02236707

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Abstract

PURPOSE: The aim of this study is to show that the diagnosis of attenuated adenomatous polyposis coli must be made with caution and certainly only after adequate colonic examination with dye-spray. METHODS: Four patients thought to have attenuated adenomatous polyposis coli on the basis of family history and the identification of fewer than 100 polyps on simple colonoscopy underwent colonoscopy with dye-spray. RESULTS: All four individuals were found to have more than 100 polyps when dye-spray was used, confirming a diagnosis of classical familial adenomatous polyposis. CONCLUSIONS: The diagnosis of familial adenomatous polyposis may be missed altogether or incorrectly assigned as attenuated adenomatous polyposis coli if dye-spray is not used at colonoscopy. Patients with a family history of familial adenomatous polyposis or colorectal cancer should be considered for dye-spray before the diagnosis of familial adenomatous polyposis is excluded or one of attenuated adenomatous polyposis coli is made.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Additional Information:	Presented at the Eighth Biennial meeting of the Leeds Castle Polyposis Group, Lorne, Australia, March 1 to 6, 1999.
Publisher:	Springer
Funders:	Imperial Cancer Research Fund
Last Modified:	04 Jun 2017 07:56
URI:	https://orca.cardiff.ac.uk/id/eprint/70131

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