The effects of the enkelphalinase inhibitor acetorphan on spontaneous locomotor-activity

Livingston, S. J., Sewell, Robert David Edmund and Smith, H. J. 1988. The effects of the enkelphalinase inhibitor acetorphan on spontaneous locomotor-activity. British Journal of Pharmacology 95 , P665-P665. 10.1111/j.1476-5381.1988.tb16615.x

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Abstract

Increased spontaneous locomotor activity (SLA) has been observed after administration of opioid peptides (Broekkamp et al. 1979; Stinus et al. 1980) and this effect has been shown to be blocked by naloxone suggesting an opioid receptor involvement. The enkephalinase inhibitor acetorphan (ACET) also increases SLA when administered intravenously (Giros et al. 1987; Michael-Titus et al. 1987) so it was the purpose of this study to examine further the locomotor activity induced by acetorphan after peripheral and central administration.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Subjects:	R Medicine > RS Pharmacy and materia medica
Publisher:	Wiley-Blackwell
ISSN:	0007-1188
Last Modified:	04 Jun 2017 07:57
URI:	https://orca.cardiff.ac.uk/id/eprint/70453

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