Strong opioids in pediatric palliative medicine [Review]

Hain, Richard D.W., Miser, Angela, Devins, Mary and Wallace, W. Hamish B. 2005. Strong opioids in pediatric palliative medicine [Review]. Pediatric Drugs 7 (1) , pp. 1-9. 10.2165/00148581-200507010-00001

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Abstract

The management of pain in the palliative care of children is somewhat different from that in adults. It also differs in approach from the management of other types of acute and chronic pain in childhood. Whereas once opioids were thought to be highly dangerous drugs, unsuitable for use in children, they have now taken their place as the mainstay for provision of good analgesia to manage moderate-to-severe pain in both malignant and non-malignant life-limiting conditions. There are relatively little clinical or laboratory data regarding opioids specifically in children. However, much of what has been published regarding the management of pain in palliative medicine in adults can be extrapolated. On saying that, early research in children does suggest some significant differences in opioid pharmacokinetics, particularly with respect to morphine clearance, which seems to be faster in adults. Thus, the use of opioids in pediatric palliative care presents some unique challenges. Confident and rational use of opioids by pediatricians, illustrated by the WHO guidelines, is essential for the adequate management of pain complicating the palliative phase in children with life-limiting conditions.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > RZ Other systems of medicine
Additional Information:	Publication Types Review Full Text Sources EBSCO Ovid Technologies, Inc. Other Literature Sources COS Scholar Universe Labome Researcher Resource - ExactAntigen/Labome Access more work from the authors - ResearchGate Medical ClinicalTrials.gov Palliative Care - MedlinePlus Health Information Pain - MedlinePlus Health Information Molecular Biology Databases MORPHINE - HSDB
Publisher:	Springer
ISSN:	1174-5878
Last Modified:	02 Nov 2015 09:37
URI:	https://orca.cardiff.ac.uk/id/eprint/70554

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