Childhood origins of arterial disease

Charakida, Marietta, Deanfield, John E. and Halcox, Julian P.J. 2007. Childhood origins of arterial disease. Current Opinion in Pediatrics 19 (5) , pp. 538-545. 10.1097/mop.0b013e3282eff585

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Abstract

PURPOSE OF REVIEW: The present article reviews the importance of classical and novel risk factors that present in childhood, track into adult life and contribute to arterial disease. The value of noninvasive techniques that can assist in characterization of preclinical atherosclerotic changes as intermediate phenotypes is also discussed. RECENT FINDINGS: Noninvasive functional and structural techniques are now available and provide the opportunity to characterize early arterial disease long before cardiovascular complications present. By using these techniques, it has been possible to quantify the impact of conventional and novel cardiovascular risk factors seen in childhood on the development of preclinical atherosclerotic changes. Scientific interest has recently widened to include not only study of mechanisms and biomarkers of injury but also mechanisms that promote vascular repair. In this new field, characterization of endothelial progenitor cells has presented new opportunities for cardiovascular research. SUMMARY: Atherosclerosis begins in early life. Primary prevention strategies for adult cardiovascular disease beginning in childhood have great potential as the disease process is most reversible at this stage. Several guidelines have recently been published for screening and implementation of appropriate therapeutic choices in early life.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > RJ Pediatrics
Uncontrolled Keywords:	Adult, Atherosclerosis/etiology, Child, Humans, Risk Factors
Additional Information:	Full Text Sources Lippincott Williams & Wilkins Ovid Technologies, Inc. Other Literature Sources COS Scholar Universe Access more work from the authors - ResearchGate Medical Atherosclerosis - MedlinePlus Health Information
Publisher:	Lippincott, Williams & Wilkins
ISSN:	1040-8703
Last Modified:	02 Nov 2015 10:19
URI:	https://orca.cardiff.ac.uk/id/eprint/70591

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