lkB kinase alpha: a link in the chain of the mammary cycle

Clarkson, Richard W. E. ORCID: https://orcid.org/0000-0001-7389-8673 2002. lkB kinase alpha: a link in the chain of the mammary cycle. Breast Cancer Research 4 , 173. 10.1186/bcr446

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Abstract

The transcription factor NF-κB exhibits altered activity in some breast cancers but the relevance of this association has not been established. Cao et al.'s elegant study recently published in Cell reveals a NF-κB-dependent signalling pathway responsible for epithelial proliferation in the mouse mammary gland. Could this mechanism, rather than prevention of apoptosis, be responsible for the reported association between NF-κB and breast cancer? Could the specificity of NF-κB modulators of the IkB kinase complex determine the fate of epithelial cells at different stages of mammary development?

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Biosciences Research Institutes & Centres > European Cancer Stem Cell Research Institute (ECSCRI)
Uncontrolled Keywords:	Apoptosis; IkB kinase; mammary; NF-κB; proliferation.
Publisher:	BioMed Central
ISSN:	1465-5411
Last Modified:	28 Oct 2022 08:29
URI:	https://orca.cardiff.ac.uk/id/eprint/70984

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