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lkB kinase alpha: a link in the chain of the mammary cycle

Clarkson, Richard W. E. ORCID: 2002. lkB kinase alpha: a link in the chain of the mammary cycle. Breast Cancer Research 4 , 173. 10.1186/bcr446

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The transcription factor NF-κB exhibits altered activity in some breast cancers but the relevance of this association has not been established. Cao et al.'s elegant study recently published in Cell reveals a NF-κB-dependent signalling pathway responsible for epithelial proliferation in the mouse mammary gland. Could this mechanism, rather than prevention of apoptosis, be responsible for the reported association between NF-κB and breast cancer? Could the specificity of NF-κB modulators of the IkB kinase complex determine the fate of epithelial cells at different stages of mammary development?

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
European Cancer Stem Cell Research Institute (ECSCRI)
Uncontrolled Keywords: Apoptosis; IkB kinase; mammary; NF-κB; proliferation.
Publisher: BioMed Central
ISSN: 1465-5411
Last Modified: 28 Oct 2022 08:29

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