Biological interaction of living cells with COSAN-based synthetic vesicles

Tarrés, Màrius, Canetta, Elisabetta, Paul, Eleanor, Forbes, Jordan, Azzouni, Karima, Viñas, Clara, Teixidor, Francesc and Harwood, Adrian J. ORCID: https://orcid.org/0000-0003-3124-5169 2015. Biological interaction of living cells with COSAN-based synthetic vesicles. Scientific Reports 5 , 7804. 10.1038/srep07804

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Abstract

Cobaltabisdicarbollide (COSAN) [3,3′-Co(1,2-C2B9H11)2]−, is a complex boron-based anion that has the unusual property of self-assembly into membranes and vesicles. These membranes have similar dimensions to biological membranes found in cells, and previously COSAN has been shown to pass through synthetic lipid membranes and those of living cells without causing breakdown of membrane barrier properties. Here, we investigate the interaction of this inorganic membrane system with living cells. We show that COSAN has no immediate effect on cell viability, and cells fully recover when COSAN is removed following exposure for hours to days. COSAN elicits a range of cell biological effects, including altered cell morphology, inhibition of cell growth and, in some cases, apoptosis. These observations reveal a new biology at the interface between inorganic, synthetic COSAN membranes and naturally occurring biological membranes.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	Q Science > QH Natural history > QH301 Biology Q Science > QH Natural history > QH426 Genetics
Additional Information:	PDF uploaded in accordance with publisher's policies at http://www.sherpa.ac.uk/romeo/issn/2045-2322/ (accessed 12.11.15).
Publisher:	Nature Publishing Group
ISSN:	2045-2322
Date of First Compliant Deposit:	30 March 2016
Date of Acceptance:	3 December 2014
Last Modified:	06 Jul 2023 17:13
URI:	https://orca.cardiff.ac.uk/id/eprint/71038

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