Increased serum levels of heat shock protein 70 are associated with low risk of coronary artery disease

Zhu, Jianhui, Quyyumi, Arshed A., Wu, Hongsheng, Csako, Gyorgy, Rott, David, Zalles-Ganley, Alexandra, Oqunmakinwa, Jibike, Halcox, Julian and Epstein, Stephen E. 2003. Increased serum levels of heat shock protein 70 are associated with low risk of coronary artery disease. Arteriosclerosis, Thrombosis, and Vascular Biology 23 (6) , pp. 1055-1059. 10.1161/01.atv.0000074899.60898.fd

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Abstract

OBJECTIVE: Previous studies suggest that heat shock protein (HSP) 60 has a contributory role in atherosclerosis development. We examined whether circulating HSP70 protein and anti-HSP70 antibodies are associated with coronary artery disease (CAD). METHODS AND RESULTS: Blood samples from 421 patients (62% men, mean age 57 years) evaluated for CAD by coronary angiography were tested. Serum HSP70 was detectable in 67% of study subjects with levels ranging from 0.2 to 27.1 ng/mL (mean, 1.08; median, 0.5). HSP70 levels were higher in non-CAD patients than CAD patients (median, 0.72 versus 0.34; P=0.0006). Individuals with HSP70 levels above the median (0.5 ng/mL) had half the risk of CAD than individuals with levels below the median (adjusted odds ratio, 0.52; 95% confidence limit, 0.32 to 0.86). The association of high HSP70 levels with low CAD risk was independent of traditional CAD risk factors (P=0.011). Disease severity (number of diseased vessels) was also inversely associated with HSP70 protein levels (P=0.010). The adjusted odds ratio of having multivessel disease for patients with high HSP70 protein levels was 0.54 (95% confidence limit, 0.36 to 0.81). In contrast, no association between anti-HSP70 IgG seropositivity and the prevalence of CAD was found (P=0.916). CONCLUSIONS: These data provide the first evidence that high levels of human HSP70 are associated with the low CAD risk, probably through its multiple protective effects on a cell's response to stress.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Additional Information:	Full Text Sources HighWire Ovid Technologies, Inc. Other Literature Sources COS Scholar Universe Labome Researcher Resource - ExactAntigen/Labome Access more work from the authors - ResearchGate Miscellaneous NCI CPTAC Assay Portal NCI CPTAC Assay Portal NCI CPTC Antibody Characterization Program
Publisher:	American Heart Association, Inc.
ISSN:	1079-5642
Date of Acceptance:	22 April 2003
Last Modified:	02 Nov 2015 11:32
URI:	https://orca.cardiff.ac.uk/id/eprint/71101

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