Angiotensin type 1 receptor antagonism reverses abnormal coronary vasomotion in atherosclerosis

Prasad, Abhiram, Halcox, Julian P.J., Waclawiw, Myron A. and Quyyumi, Arshed A. 2001. Angiotensin type 1 receptor antagonism reverses abnormal coronary vasomotion in atherosclerosis. Journal of the American College of Cardiology 38 (4) , pp. 1089-1095.

Full text not available from this repository.

Abstract

OBJECTIVES: This study was performed to determine whether angiotensin type 1 (AT1) receptor inhibition improves abnormal coronary vasomotion and endothelial dysfunction in patients with atherosclerosis or its risk factors. BACKGROUND: Endothelial dysfunction, an early feature of atherosclerosis, contributes to abnormal vasomotion during stress. Angiotensin II may contribute to endothelial dysfunction in atherosclerosis. METHODS: In 25 patients, mean age 59 +/- 2 years, with atherosclerosis or its risk factors, we measured coronary vasomotion during flow-mediated dilation (FMD) in response to adenosine, cold pressor test (CPT) and exercise before and after AT1 receptor blockade with intracoronary losartan (5 mg). RESULTS: Losartan did not alter resting coronary vascular tone, but epicardial FMD improved from 5.6 +/- 1.5% to 8.9 +/- 1.8% (p = 0.02). Abnormal epicardial vasomotion during CPT and exercise also improved with losartan from -1.7 +/- 0.8% to 1.5 +/- 0.1% (p = 0.02) and -0.6 +/- 0.9% to 3.4 +/- 1.2% (p = 0.009), respectively. Improvement in epicardial vasomotion was most prominent in segments with baseline endothelial dysfunction evidenced as constriction during stress. Microvascular dilation during adenosine, an endothelium-independent response, was unchanged with losartan. CONCLUSIONS: Inhibition of the coronary vascular AT1 receptors in patients with atherosclerosis improves epicardial vasomotion during stress, probably by improving endothelial dysfunction. Whether AT1 receptor blockade will provide long-term therapeutic benefits in atherosclerosis needs further investigation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Additional Information:	Full Text Sources Elsevier Science Ingenta plc Gale Databases Other Literature Sources Labome Researcher Resource - ExactAntigen/Labome Access more work from the authors - ResearchGate Medical Blood Pressure Medicines - MedlinePlus Health Information Coronary Artery Disease - MedlinePlus Health Information Molecular Biology Databases LOSARTAN POTASSIUM - HSDB
Publisher:	Elsevier
ISSN:	0735-1097
Related URLs:	Publisher
Date of Acceptance:	26 June 2001
Last Modified:	02 Nov 2015 11:50
URI:	https://orca.cardiff.ac.uk/id/eprint/71119

Citation Data

Cited 50 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item