Effect of breathing low concentrations of volatile anaesthetic agents on incidence of adverse airway events

Goodwin, Naomi, Strong, P. J., Sudhir, G., Wilkes, A. R. and Hall, Judith Elizabeth ORCID: https://orcid.org/0000-0002-6770-7372 2005. Effect of breathing low concentrations of volatile anaesthetic agents on incidence of adverse airway events. Anaesthesia -London- 60 (10) , pp. 955-959. 10.1111/j.1365-2044.2005.04279.x

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Abstract

The effect of breathing 0.1 minimum alveolar concentrations (MAC) of desflurane or isoflurane for three minutes on the incidence of adverse airway events on a subsequent breath of 2 MAC was investigated. Twenty-five volunteers known to develop an adverse airway event to desflurane or isoflurane took part in the study. Each volunteer was exposed to isoflurane and desflurane at least 24 h apart. Volunteers were assessed for adverse airway events while breathing 2 MAC inhalational anaesthetic following breathing 100% O(2) for 3 min. This was repeated with 0.1 MAC inhalational anaesthetic in oxygen instead of 100% O(2). Adverse airway events decreased from 88% to 40% when tests were conducted with desflurane (p = 0.002). With isoflurane, the reduction from 60% to 52% was not statistically significant (p = 0.774). Breathing low concentrations of desflurane decreases the incidence of adverse airway events on subsequent inhalation of higher concentration of desflurane.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > RZ Other systems of medicine
Publisher:	Wiley-Blackwell
ISSN:	0003-2409
Last Modified:	28 Oct 2022 08:35
URI:	https://orca.cardiff.ac.uk/id/eprint/71306

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