Silver nanoparticle based antibacterial methacrylate hydrogels potential for bone graft applications

González-Sánchez, M. Isabel, Perni, Stefano, Tommasi, Giacomo, Morris, Nathanael Glyn, Hawkins, Karl, López-Cabarcos, Enrique and Prokopovich, Polina ORCID: https://orcid.org/0000-0002-5700-9570 2015. Silver nanoparticle based antibacterial methacrylate hydrogels potential for bone graft applications. Materials Science and Engineering C 50 , pp. 332-340. 10.1016/j.msec.2015.02.002

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Abstract

Infections are frequent and very undesired occurrences after orthopedic procedures; furthermore, the growing concern caused by the rise in antibiotic resistance is progressively dwindling the efficacy of such drugs. Artificial bone graft materials could solve some of the problems associated with the gold standard use of natural bone graft such as limited bone material, pain at the donor site and rejections if donor tissue is used. We have previously described new acrylate base nanocomposite hydrogels as bone graft materials. In the present paper, we describe the integration of silver nanoparticles in the polymeric mineralized biomaterial to provide non-antibiotic antibacterial activity against Staphylococcus epidermidis and Methicillin-resistant Staphylococcus aureus. Two different crosslinking degrees were tested and the silver nanoparticles were integrated into the composite matrix by means of three different methods: entrapment in the polymeric hydrogel before the mineralization; diffusion during the process of calcium phosphate crystallization and adsorption post-mineralization. The latter being generally the most effective method of encapsulation; however, the adsorption of silver nanoparticles inside the pores of the biomaterial led to a decreasing antibacterial activity for adsorption time longer than 2 days.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Pharmacy
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords:	Hydrogels; Silver; Nanoparticles; Infections; Staphylococcus epidermidis; Methicillin-resistant Staphylococcus aureus (MRSA)
Publisher:	Elsevier
ISSN:	0928-4931
Funders:	Arthritis Research UK
Date of First Compliant Deposit:	30 March 2016
Date of Acceptance:	6 February 2015
Last Modified:	02 May 2023 17:20
URI:	https://orca.cardiff.ac.uk/id/eprint/71335

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