Deletion of the homeobox gene PRX-2 affects fetal but not adult fibroblast wound healing responses

White, Philip, Thomas, David William ORCID: https://orcid.org/0000-0001-7319-5820, Fong, Steven, Stelnicki, Eric, Meijlink, Fritz, Largman, Corey and Stephens, Philip ORCID: https://orcid.org/0000-0002-0840-4996 2003. Deletion of the homeobox gene PRX-2 affects fetal but not adult fibroblast wound healing responses. Journal Of Investigative Dermatology 120 (1) , pp. 135-144. 10.1046/j.1523-1747.2003.12015.x

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Abstract

The phenotype of fibroblasts repopulating experimental wounds in vivo has been shown to influence both wound healing responses and clinical outcome. Recent studies have demonstrated that the human homeobox gene PRX-2 is strongly upregulated in fibroblasts within fetal, but not adult, mesenchymal tissues during healing. Differential homeobox gene expression by fibroblasts may therefore be important in mediating the scarless healing exhibited in early fetal wounds. RNase protection analysis demonstrated that murine Prx-2 expression was involved in fetal but not adult wound healing responses in vitro. Using fibroblasts established from homozygous mutant (Prx-2-/-) and wild-type (Prx-2+/+) murine skin tissues it was demonstrated that Prx-2 affected a number of fetal fibroblastic responses believed to be important in mediating scarless healing in vivo; namely cellular proliferation, extracellular matrix reorganization, and matrix metalloproteinase 2 and hyaluronic acid production. These data demonstrate how Prx-2 may contribute to the regulation of fetal, but not adult, fibroblasts and ultimately the wound healing phenotype. This study provides further evidence for the importance of homeobox transcription factors in the regulation of scarless wound healing. A further understanding of these processes will, it is hoped, enable the targeting of specific therapies in wound healing, both to effect scarless healing and to stimulate healing in chronic, nonhealing wounds such as venous leg ulcers.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Dentistry Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > RK Dentistry
Uncontrolled Keywords:	fibroblast ; homeobox gene ; Prx-2 ; wound healing
Publisher:	Blackwell Publishing
ISSN:	0022-202X
Last Modified:	06 Nov 2024 22:27
URI:	https://orca.cardiff.ac.uk/id/eprint/714

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