Acute oxygen sensing: diverse but convergent mechanisms in airway and arterial chemoreceptors

Peers, Chris and Kemp, Paul J. ORCID: https://orcid.org/0000-0003-2773-973X 2001. Acute oxygen sensing: diverse but convergent mechanisms in airway and arterial chemoreceptors. Respiratory Research 2 , pp. 145-149. 10.1186/rr51

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Abstract

Airway neuroepithelial bodies sense changes in inspired O2, whereas arterial O2 levels are monitored primarily by the carotid body. Both respond to hypoxia by initiating corrective cardiorespiratory reflexes, thereby optimising gas exchange in the face of a potentially deleterious O2 supply. One unifying theme underpinning chemotransduction in these tissues is K+ channel inhibition. However, the transduction components, from O2 sensor to K+ channel, display considerable tissue specificity yet result in analogous end points. Here we highlight how emerging data are contributing to a more complete understanding of O2 chemosensing at the molecular level.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	BioMed Central
Date of First Compliant Deposit:	30 March 2016
Last Modified:	02 May 2023 20:57
URI:	https://orca.cardiff.ac.uk/id/eprint/71653

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