Structural plasticity within the barrel cortex during initial phases of whisker-dependent learning

Kuhlman, Sandra J., O'Connor, Daniel H., Fox, Kevin ORCID: https://orcid.org/0000-0002-2563-112X and Svoboda, Karel 2014. Structural plasticity within the barrel cortex during initial phases of whisker-dependent learning. Journal of Neuroscience 34 (17) 10.1523/JNEUROSCI.4919-12.2014

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Abstract

We report learning-related structural plasticity in layer 1 branches of pyramidal neurons in the barrel cortex, a known site of sensorimotor integration. In mice learning an active, whisker-dependent object localization task, layer 2/3 neurons showed enhanced spine growth during initial skill acquisition that both preceded and predicted expert performance. Preexisting spines were stabilized and new persistent spines were formed. These findings suggest rapid changes in connectivity between motor centers and sensory cortex guide subsequent sensorimotor learning.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Subjects:	Q Science > QR Microbiology
Publisher:	Society for Neuroscience
ISSN:	1529-2401
Date of Acceptance:	23 March 2014
Last Modified:	28 Oct 2022 08:40
URI:	https://orca.cardiff.ac.uk/id/eprint/71715

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