Cell therapy for Huntington's Disease

Rosser, Anne Elizabeth ORCID: https://orcid.org/0000-0002-4716-4753 and Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 2014. Cell therapy for Huntington's Disease. Advances in Clinical Neuroscience and Rehabilitation 14 (5) , pp. 18-21.

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Abstract

Early clinical trials of foetal striatal cell transplants in HD patients have shown initial indications of functional response, but the recovery has not (as yet) been shown to be reliable or sustained. In experimental animals, foetal striatal transplants can integrate into host circuitry and alleviate aspects of motor and cognitive disease, maintaining the prospect for an effective reconstructive cell therapy in HD patients. Cell transplantation can also be used for sustained and controlled delivery of neuroprotective and trophic molecules into precise deep brain targets, opening the prospect for alternative strategies to cell therapy which should be seen as complementary, not mutually exclusive.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	Q Science > QH Natural history > QH426 Genetics R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Whitehouse Publishing
ISSN:	1473-9348
Last Modified:	28 Oct 2022 08:41
URI:	https://orca.cardiff.ac.uk/id/eprint/71731

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