Langabeer, S. E., Walker, Helen, Rogers, J. R., Burnett, Alan Kenneth, Wheatley, K., Swirsky, D., Goldstone, A. H. and Linch, D. C. 1997. Incidence of AML1/ETO fusion transcripts in patients entered into the MRC AML trials. British Journal of Haematology 99 (4) , pp. 925-928. 10.1046/j.1365-2141.1997.4663270.x |
Abstract
Acute myeloid leukaemia (AML) with the t(8;21)(q22;q22) is deemed to be a 'good-risk' disease. 396 patients with AML at diagnosis were screened for the presence of t(8;21) and AML1/ETO fusion transcripts by cytogenetic and RT-PCR techniques respectively. 32 cases of t(8;21) were detected, all of which were also PCR positive. A further 19 cases were detected at the molecular level, predominantly but not exclusively in M1 and M2 FAB types. Approximately 12% of all new cases of AML are estimated to have AML1/ETO fusion transcripts and it is suggested that molecular screening should be performed in all cases with the possible exception of the M3 FAB type.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine |
Subjects: | R Medicine > R Medicine (General) R Medicine > RZ Other systems of medicine |
Publisher: | Wiley-Blackwell |
ISSN: | 0007-1048 |
Last Modified: | 08 Jan 2020 03:22 |
URI: | https://orca.cardiff.ac.uk/id/eprint/71743 |
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