Localization of MRX82: A new nonsyndromic X-linked mental retardation locus to Xq24-q25 in a Basque family

Martinez, Francisco, Martinez Garay, Isabel ORCID: https://orcid.org/0000-0001-6849-7496, Oltra, Silvestre, Molto, Maria Dolores, Orellana, Carmen, Monfort, Sandra, Prieto, Felix and Tejada, Isabel 2004. Localization of MRX82: A new nonsyndromic X-linked mental retardation locus to Xq24-q25 in a Basque family. American Journal of Medical Genetics 131A (2) , pp. 174-178. 10.1002/ajmg.a.30352

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Abstract

Clinical and molecular studies are reported on a Basque family (MRX82) with nonsyndromic X-linked mental retardation (XLMR) in five affected males. A total of 38 microsatellite markers were typed. The XLMR locus has been linked to DXS8067, DXS1001, DXS425, DXS7877, and DXS1183 with a maximum LOD score of 2.4. The haplotype studies and multipoint linkage analysis suggest a localization of the MRX82 locus to an interval of 7.6 Mb defined by markers DXS6805 and DXS7346, in Xq24 and Xq25, respectively. No gene contained in this interval has been so far associated with nonsyndromic mental retardation, except for GRIA3, disrupted by a balanced translocation in a female patient with bipolar affective disorder and mental retardation. However, the search for mutations of this gene did not showed a pathogenic mutation in the present family. Given that there are other eight MRX families overlapping this interval, none of them with known mutation, we conclude that at least one new gene responsible for nonsyndromic mental retardation is located in this region. © 2004 Wiley-Liss, Inc.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Subjects:	Q Science > QH Natural history > QH426 Genetics
Uncontrolled Keywords:	mental retardation; Xq24; GRIA3; AGTR2; XLMR; linkage analysis
Publisher:	Wiley
ISSN:	0148-7299
Last Modified:	28 Oct 2022 08:41
URI:	https://orca.cardiff.ac.uk/id/eprint/71777

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