Lee, Patrick C. L., Jawad, Mutaz S. M.., Hull, J. David, West, Will H. L., Shaw, Kerry and Eccles, Ronald  ORCID: https://orcid.org/0000-0001-9492-2062
2005.
The antitussive effect of placebo treatment on cough associated with acute upper respiratory infection.
Psychosomatic Medicine
67
(2)
, pp. 314-317.
10.1097/01.psy.0000155667.59662.92
|
Abstract
Objective: The objective of this study was to determine the effects of a placebo treatment on cough in patients with cough associated with acute upper respiratory tract infection (URTI). Methods: Patients with dry or slightly productive cough associated with a history of URTI were recruited. Cough frequency (CF) over 15 minutes was recorded by means of a microphone connected to a pen recorder. Cough suppression time (CST) was recorded when patients were instructed by means of a red light to try not to cough. Patients received either a single dose of vitamin E (placebo treatment) or no treatment. CF and CST were recorded before and 15 minutes after treatment. Results: Twenty-seven patients were randomized to placebo treatment and 27 to the no-treatment group (mean age 22.6 years). The median difference between post- and pretreatment CF was -3 in the no-treatment group and -18 in the placebo group (p = .0003). There was a significant increase in CST in the placebo group compared with no treatment (p = .027). Conclusions: The results demonstrate that placebo treatment has significant antitussive activity. This placebo effect may be related to generation of central neurotransmitters such as endogenous opioids. CF = cough frequency; CST = cough suppression time.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Biosciences |
| Subjects: | Q Science > QR Microbiology > QR355 Virology |
| Publisher: | American Psychosomatic Society |
| ISSN: | 0033-3174 |
| Last Modified: | 28 Oct 2022 08:42 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/71811 |
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