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Ergometrine-induced arterial dilatation: An endothelium-mediated effect

Griffith, T. M., Edwards, David Hughes, Lewis, M. J. and Henderson, A. H. 1984. Ergometrine-induced arterial dilatation: An endothelium-mediated effect. Journal of Molecular and Cellular Cardiology 16 (5) , pp. 479-482. 10.1016/S0022-2828(84)80619-7

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Ergometrine has generally been regarded as a vasoconstrictor and is used clinically to provoke coronary vasospasm in susceptible patients [3, 8, 9]. The ergometrine response appears however to be complex in that it can be biphasic, the constrictor response being preceded by an initial dilator response in experimental models [4]. The explanation for this is unknown, as is the underlying mechanism responsible for the clinical condition of coronary vasospasm. We have investigated this biphasic response in isolated artery preparations and shown that the dilator component is due to ergometrine-induced release of endothelium-derived relaxant factor (EDRF).

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Endothelium-derived relaxant factor, Ergometrine, Coronary artery, Vasospasm
Publisher: Elsevier
ISSN: 0022-2828
Last Modified: 04 Jun 2017 08:03

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