Dhanjal, Tarvinder S., Lellouche, Nicolas, Von Ruhland, Christopher, Abehsira, Guillaume, Edwards, David H., Dubois-Randé, Jean-Luc, Moschonas, Konstantinos, Teiger, Emmanuel, Williams, Alan J. and George, Christopher H. 2017. Massive accumulation of myofibroblasts in the critical isthmus is associated with ventricular tachycardia inducibility in post-infarct swine heart. Journal of the American College of Cardiology: Clinical Electrophysiology 3 (7) , pp. 703-714. 10.1016/j.jacep.2016.11.010 |
George, Christopher H. and Edwards, David H. 2016. Decoding Ca2+ signals as a non-electrophysiological method for assessing drug toxicity in stem cell-derived cardiomyocytes. Clements, Michael and Roquemore, Elizabeth P., eds. Stem Cell-Derived Models in Toxicology, New York, NY: Springer, pp. 173-190. (10.1007/978-1-4939-6661-5_9) |
Dhanjal, Tarvinder, Lellouche, Nicolas, Von Ruhland, Christopher John, Edwards, David Hughes, George, Christopher and Williams, Alan 2016. LAVA sites are histologically closely related to critical isthmus sites in post-infarct ventricular tachycardia. Presented at: Heart Rhythm 2016 - 37th Annual Scientific Sessions, San Francisco, CA, USA, 4 May 2016. |
Jones, Aled, Edwards, David Hughes and Williams, Alan John 2016. Characterisation of cardiomyocytes derived from human induced pluripotent stem cells as monolayers [Poster Abstract]. The Lancet 387 (S1) , S56. 10.1016/S0140-6736(16)00443-8 |
Jones, Aled R., Edwards, David Hughes, Cummins, Michael J., Williams, Alan John and George, Christopher H. 2016. A systematized approach to investigate Ca2+ synchronization in iPSC-derived cardiomyocyte networks. Biophysical Journal 110 (3) , 435a. 10.1016/j.bpj.2015.11.2346 |
Schepelmann, M. ORCID: https://orcid.org/0000-0002-7017-5426, Yarova, P. L., Lopez-Fernandez, I., Davies, T. S., Brennan, S. C. ORCID: https://orcid.org/0000-0002-8719-4367, Edwards, P. J., Aggarwal, A., Graca, J., Rietdorf, K., Matchkov, V., Fenton, R. A., Chang, W., Krssak, M., Stewart, A., Broadley, K. J. ORCID: https://orcid.org/0000-0002-3339-2050, Ward, D. T., Price, S. A., Edwards, D. H., Kemp, P. J. ORCID: https://orcid.org/0000-0003-2773-973X and Riccardi, D. ORCID: https://orcid.org/0000-0002-7322-3163 2016. The vascular Ca2+-sensing receptor regulates blood vessel tone and blood pressure. American Journal of Physiology - Cell Physiology 310 (3) , C193-C204. 10.1152/ajpcell.00248.2015 |
Jones, Aled, Edwards, David Hughes, Cummins, Michael J., Williams, Alan John and George, Christopher H. 2016. A systemized approach to investigate Ca2+ synchronization in clusters of human induced pluripotent stem-cell derived cardiomyocytes. Frontiers in Cell and Developmental Biology 3 , 89. 10.3389/fcell.2015.00089 |
Dhanjal, Tarvinder, Lellouche, Nicolas, Von Ruhland, Christopher, Edwards, David, George, Christopher and Williams, Alan 2016. Increased myofibroblast densities are specific to critical isthmus sites in post-infarct re-entrant ventricular tachycardia. Presented at: Heart Rhythm Society, San Francisco, May 2016. |
Edwards, David Hughes 2013. Local, integrated control of blood flow: Professor Tudor Griffith Memorial. Autonomic Neuroscience-Basic & Clinical 178 (1-2) , pp. 4-8. 10.1016/j.autneu.2013.02.023 |
Edwards, David Hughes, Li, Yiwen, Ellinsworth, David Carl and Griffith, Tudor M. 2013. The effect of inorganic arsenic on endothelium-dependent relaxation: Role of NADPH oxidase and hydrogen peroxide. Toxicology 306 , pp. 50-58. 10.1016/j.tox.2013.01.019 |
Edwards, David, Li, Yiwen and Griffith, Tudor Morley 2011. Hydrogen peroxide potentiates the EDHF phenomenon by promoting endothelial Ca2+ mobilization. Arteriosclerosis Thrombosis and Vascular Biology 28 (10) , pp. 1774-1781. 10.1161/ATVBAHA.108.172692 |
Garry, Ambroise, Edwards, David Hughes, Fallis, Ian Andrew ORCID: https://orcid.org/0000-0001-7361-0182, Jenkins, Robert Leyshon and Griffith, Tudor Morley 2009. Ascorbic acid and tetrahydrobiopterin potentiate the EDHF phenomenon by generating hydrogen peroxide. Cardiovascular Research 84 (2) , pp. 218-226. 10.1093/cvr/cvp235 |
Fernandez-Rodriguez, Sofia, Edwards, David Hughes, Newton, B. and Griffith, Tudor Morley 2009. Attenuated store-operated Ca2+ entry underpins the dual inhibition of nitric oxide and EDHF-type relaxations by iodinated contrast media. Cardiovascular Research 84 (3) , pp. 470-478. 10.1093/cvr/cvp239 |
Edwards, David Hughes, Chaytor, Andrew Thomas, Bakker, Linda Margaretha and Griffith, Tudor Morley 2005. Modulation of gap-junction-dependent arterial relaxation by ascorbic acid. Journal of Vascular Research 44 (5) , pp. 410-422. 10.1159/000104254 |
Griffith, Tudor Morley, Chaytor, Andrew Thomas, Edwards, David Hughes and Bakker, Linda Margaretha 2005. 5-Methyltetrahydrofolate and tetrahydrobiopterin can modulate electrotonically mediated endothelium-dependent vascular relaxation. Proceedings of the National Academy of Sciences 102 (19) , pp. 7008-7013. 10.1073/pnas.0408919102 |
Chaytor, Andrew Thomas, Bakker, Linda Margaretha, Edwards, David Hughes and Griffith, Tudor Morley 2005. Connexin-mimetic peptides dissociate electrotonic EDHF-type signalling via myoendothelial and smooth muscle gap junctions in the rabbit iliac artery. British Journal of Pharmacology 144 (1) , pp. 108-114. 10.1038/sj.bjp.0706046 |
Griffith, Tudor M., Chaytor, Andrew T. and Edwards, David Hughes 2004. The obligatory link: role of gap junctional communication in endothelium-dependent smooth muscle hyperpolarization. Pharmacological Research 49 (6) , pp. 551-564. 10.1016/j.phrs.2003.11.014 |
Griffith, Tudor M., Chaytor, Andrew T., Edwards, David Hughes, Daverio, Felice and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2004. Enhanced inhibition of the EDHF phenomenon by a phenyl methoxyalaninyl phosphoramidate derivative of dideoxyadenosine. British Journal of Pharmacology 142 (1) , pp. 27-30. 10.1038/sj.bjp.0705782 |
Chaytor, Andrew Thomas, Edwards, David Hughes, Bakker, Linda Margaretha and Griffith, Tudor Morley 2003. Distinct hyperpolarizing and relaxant roles for gap junctions and endothelium-derived H2O2 in NO-independent relaxations of rabbit arteries. Proceedings of the National Academy of Sciences 100 (25) , pp. 15212-15217. 10.1073/pnas.2435030100 |
Parthimos, Dimitris ORCID: https://orcid.org/0000-0003-3852-323X, Edwards, David Hughes and Griffith, Tudor Morley 2003. Shil'nikov homoclinic chaos is intimately related to type-III intermittency in isolated rabbit arteries: role of nitric oxide. Phys Rev E Stat Nonlin Soft Matter Phys 67 (5) , 051922. 10.1103/PhysRevE.67.051922 |
Ujiie, Hiroshi, Edwards, David Hughes and Griffith, Tudor M. 2002. Endogenous nitric oxide synthesis differentially modulates pressure-flow and pressure-conductance relationships in the internal and external carotid artery circulations of the rat. Neurologia medico-chirurgica 42 (12) , pp. 527-535. 10.2176/nmc.42.527 |
Griffith, Tudor Morley, Chaytor, Andrew Thomas, Taylor, Hannah J., Giddings, Beverley Diane and Edwards, David Hughes 2002. cAMP facilitates EDHF-type relaxations in conduit arteries by enhancing electrotonic conduction via gap junctions. Proceedings of the National Academy of Sciences 99 (9) , pp. 6392-6397. 10.1073/pnas.092089799 |
Parthimos, Dimitris ORCID: https://orcid.org/0000-0003-3852-323X, Edwards, David Hughes and Griffith, Tudor Morley 2001. Universal scaling properties of type-I intermittent chaos in isolated resistance arteries are unaffected by endogenous nitric oxide synthesis. Phys Rev E Stat Nonlin Soft Matter Phys 64 (6) , 061906. 10.1103/PhysRevE.64.061906 |
Chaytor, Andrew Thomas, Martin, Patricia Esther Mary, Edwards, David Hughes and Griffith, Tudor Morley 2001. Gap junctional communication underpins EDHF-type relaxations evoked by ACh in the rat hepatic artery. American Journal of Physiology Heart and Circulatory Physiology 280 (6) , H2441-2450. |
Taylor, Hannah J., Chaytor, Andrew T., Edwards, David Hughes and Griffith, Tudor M. 2001. Gap junction-dependent increases in smooth muscle cAMP underpin the EDHF phenomenon in rabbit arteries. Biochemical and Biophysical Research Communications 283 (3) , pp. 583-589. 10.1006/bbrc.2001.4791 |
Parthimos, Dimitris ORCID: https://orcid.org/0000-0003-3852-323X, Edwards, David Hughes and Griffith, T. M. 1999. Minimal model of arterial chaos generated by coupled intracellular and membrane Ca2+oscillators. American Journal of Physiology - Heart and Circulatory Physiology 277 (3 pt 2) , H1119-H1144. |
De Brouwer, S., Edwards, David Hughes and Griffith, T. M. 1998. Simplification of the quasiperiodic route to chaos in agonist-induced vasomotion by iterative circle maps. American Journal of Physiology - Heart and Circulatory Physiology 274 (4 pt 2) , H1315-H1326. |
Griffith, T. M., Parthimos, Dimitris ORCID: https://orcid.org/0000-0003-3852-323X, Crombie, J. and Edwards, David Hughes 1997. Critical scaling and type-III intermittent chaos in isolated rabbit resistance arteries [Rapid communication]. Physical Review E 56 (6) , R6287-R6290. 10.1103/PhysRevE.56.R6287 |
Edwards, David Hughes and Griffith, T. M. 1997. Entrained ion transport systems generate the membrane component of chaotic agonist-induced vasomotion. American Journal of Physiology - Heart and Circulatory Physiology 273 (2 pt 2) , H909-H920. |
Griffith, T. M. and Edwards, David Hughes 1997. Ca2+ sequestration as a determinant of chaos and mixed-mode dynamics in agonist-induced vasomotion. American Journal of Physiology - Heart and Circulatory Physiology 272 (4 pt 2) , H1696-H1709. |
Parthimos, Dimitris ORCID: https://orcid.org/0000-0003-3852-323X, Edwards, David Hughes and Griffith, T. M. 1996. Comparison of chaotic and sinusoidal vasomotion in the regulation of microvascular flow. Cardiovascular Research 31 (3) , pp. 388-399. 10.1016/S0008-6363(95)00123-9 |
Griffith, T. M. and Edwards, David Hughes 1995. Complexity of chaotic vasomotion is insensitive to flow and pressure but can be regulated by external control. American Journal of Physiology - Heart and Circulatory Physiology 269 (2 pt 2) , H656-H668. |
Pugh, Neil D. ORCID: https://orcid.org/0000-0002-6721-2265, Hutcheson, Iain Robert, Edwards, David Hughes, Nossen, J. Ø., Karlsson, J. O. G. and Griffith, T. M. 1995. Angiographic contrast media relax isolated rabbit aorta through an endothelium-independent mechanism that may not depend on the presence of the iodine atom. British Journal of Radiology 68 (805) , pp. 23-26. 10.1259/0007-1285-68-805-23 |
Griffith, T. M. and Edwards, David Hughes 1994. EDRF suppresses chaotic pressure oscillations in isolated resistance artery without influencing intrinsic complexity. American Journal of Physiology - Heart and Circulatory Physiology 266 (5 pt 2) , H1786-H1800. |
Griffith, T. M. and Edwards, David Hughes 1994. Fractal analysis of role of smooth muscle Ca2+ fluxes in genesis of chaotic arterial pressure oscillations. American Journal of Physiology - Heart and Circulatory Physiology 266 (5 pt 2) , H1801-H1811. |
Griffith, Tudor Morley, Edwards, David and Hutcheson, Iain Richard 1993. Flow pulsatility, arterial chaos and EDRF activity. Presented at: Recent Advances in Coronary Circulation: Two Symposia, Fukushima, Japan, 1993. Published in: Maruyama, Y., Kajiya, F., Hoffman, J. I. E. and Spaan, J. A. E. eds. Recent Advances in Coronary Circulation: Proceedings of Two Symposia, Fukushima, Japan, 1993. Tokyo: Springer, pp. 160-170. |
Renowden, S., Edwards, David Hughes and Griffith, T. M. 1992. Impaired cyclic nucleotide-mediated vasorelaxation may contribute to closure of the human umbilical artery after birth. British Journal of Pharmacology 106 (2) , pp. 348-353. 10.1111/j.1476-5381.1992.tb14339.x |
Edwards, David Hughes, Byrne, James V. and Griffith, Tudor M. 1992. The effect of chronic subarachnoid hemorrhage on basal endothelium-derived relaxing factor activity in intrathecal cerebral arteries. Journal of Neurosurgery 76 (5) , pp. 830-837. 10.3171/jns.1992.76.5.0830 |
Griffith, Tudor Morley, Hutcheson, Iain Richard, Randall, M. D. and Edwards, David Hughes 1991. Role of flow in endothelial-mediated responses. Presented at: Third International Symposium on Resistance Arteries, Skörping, Denmark, 21-25 May 1991. Published in: Mulvaney, Michael J., Aalkjaer, C., Heagerty, A. M., Nhyborg, N. C. B. and Standgaard, S. eds. Resistance Arteries: Structure and Function: Proceedings of the Third International Symposium on Resistance Arteries, Rebild, Skörping, Denmark, 21-25 May 1991. International Congress Series (974) Amsterdam: Excerpta Medica, pp. 204-207. |
Randall, Michael D., Edwards, David Hughes and Griffith, Tudor M. 1990. Activities of endothelin-1 in the vascular network of the rabbit ear: a microangiographic study. British Journal of Pharmacology 101 (4) , pp. 781-788. 10.1111/j.1476-5381.1990.tb14157.x |
Griffith, T. M. and Edwards, David Hughes 1990. Basal EDRF activity helps to keep the geometrical configuration of arterial bifurcations close to the murray optimum. Journal of Theoretical Biology 146 (4) , pp. 545-573. 10.1016/S0022-5193(05)80378-9 |
Griffith, T. M. and Edwards, David Hughes 1990. Myogenic autoregulation of flow may be inversely related to endothelium-derived relaxing factor activity. American Journal of Physiology - Heart and Circulatory Physiology 258 (4 pt 2) , H1171-H1180. |
Burton, Gerardine A., Griffith, T. M. and Edwards, David Hughes 1989. EDRF-mediated dilatation in the rat isolated perfused kidney: a microangiographic study. British Journal of Pharmacology 98 (4) , pp. 1207-1212. 10.1111/j.1476-5381.1989.tb12666.x |
Byrne, J. V., Griffith, T. M., Edwards, David Hughes, Harrison, T. J. and Johnston, K. R. 1989. Investigation of the vasoconstrictor action of subarachnoid haemoglobin in the pig cerebral circulation in vivo. British Journal of Pharmacology 97 (3) , pp. 669-674. 10.1111/j.1476-5381.1989.tb12002.x |
Griffith, T. M., Edwards, David Hughes, Davies, R. Ll. and Henderson, A. H. 1989. The role of EDRF in flow distribution: A microangiographic study of the rabbit isolated ear. Microvascular Research 37 (2) , pp. 162-177. 10.1016/0026-2862(89)90035-6 |
Griffith, T. M., Edwards, David Hughes, Davies, R. Ll., Harrison, T. J. and Evans, K. T. 1988. Endothelium-derived relaxing factor (EDRF) and resistance vessels in an intact vascular bed: a microangiographic study of the rabbit isolated ear. British Journal of Pharmacology 93 (3) , pp. 654-662. 10.1111/j.1476-5381.1988.tb10323.x |
Griffith, T. M., Edwards, David Hughes, Davies, R. Ll., Harrison, T. J. and Evans, K. T. 1987. EDRF coordinates the behaviour of vascular resistance vessels. Nature 329 (6138) , pp. 442-445. 10.1038/329442a0 |
Griffith, T. M., Edwards, David Hughes and Henderson, A. H. 1987. Unstimulated release of endothelium derived relaxing factor is independent of mitochondrial ATP generation. Cardiovascular Research 21 (8) , pp. 565-568. 10.1093/cvr/21.8.565 |
Edwards, David Hughes, Griffith, T. M., Ryley, H. C. and Henderson, A. H. 1986. Haptoglobin-haemoglobin complex in human plasma inhibits endothelium dependent relaxation: evidence that endothelium derived relaxing factor acts as a local autocoid. Cardiovascular Research 20 (8) , pp. 549-556. 10.1093/cvr/20.8.549 |
White, David G., Lewis, Malcolm J., Griffith, Tudor M., Edwards, David Hughes and Henderson, Andrew H. 1986. Influence of endothelium on drug-induced relaxation of the rabbit aorta. European Journal of Pharmacology 121 (1) , pp. 19-23. 10.1016/0014-2999(86)90387-0 |
Griffith, Tudor M., Edwards, David Hughes, Newby, Andrew C., Lewis, Malcolm J. and Henderson, Andrew H. 1986. Production of endothelium derived relaxant factor is dependent on oxidative phosphorylation and extracellular calcium. Cardiovascular Research 20 (1) , pp. 7-12. 10.1093/cvr/20.1.7 |
Griffith, Tudor M., Edwards, David Hughes, Lewis, Malcolm J. and Henderson, Andrew H. 1985. Evidence that cyclic guanosine monophosphate (cGMP) mediates endothelium-dependent relaxation. European Journal of Pharmacology 112 (2) , pp. 195-202. 10.1016/0014-2999(85)90496-0 |
Griffith, T. M., Henderson, A. H., Edwards, David Hughes and Lewis, M. J. 1984. Isolated perfused rabbit coronary artery and aortic strip preparations: the role of endothelium-derived relaxant factor. The Journal of Physiology 351 (1) , pp. 13-24. 10.1113/jphysiol.1984.sp015228 |
Griffith, T. M., Edwards, David Hughes, Lewis, M. J. and Henderson, A. H. 1984. Ergometrine-induced arterial dilatation: An endothelium-mediated effect. Journal of Molecular and Cellular Cardiology 16 (5) , pp. 479-482. 10.1016/S0022-2828(84)80619-7 |
Griffith, T. M., Edwards, David Hughes, Lewis, M. J., Newby, A. C. and Henderson, A. H. 1984. The nature of endothelium-derived vascular relaxant factor[Letter]. Nature 308 (5960) , pp. 645-647. 10.1038/308645a0 |
Griffith, T. M., Henderson, A. H., Edwards, David Hughes and Lewis, M. J. 1984. Evidence for a primary role of cGMP in endothelium-mediated vasodilatation [Abstract]. The Journal of Physiology 350 (Suppl.) , p. 46. 10.1113/jphysiol.1984.sp015225 |
Griffith, T. M., Edwards, David Hughes, Lewis, M. J. and Henderson, A. H. 1984. Partial characterisation of endothelial relaxing factor [Communication]. Clinical Science 66 (2) , 23P-23P. 10.1042/cs066023Pb |
Griffith, T. M., Henderson, A. H., Edwards, David Hughes, Lewis, M. J. and Newby, A. C. 1983. The nature of endothelial relaxing factor in rabbit aortic preparations [Abstract]. The Journal of Physiology 345 (Suppl.) , p. 171. 10.1113/jphysiol.1983.sp015002 |
Griffith, T. M., Edwards, David Hughes, Lewis, M. J. and Henderson, A. H. 1983. The nature of endothelial relaxing factor (ERF) [Abstract]. Circulation 68 (4) , p. 33. |