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Evidence that cyclic guanosine monophosphate (cGMP) mediates endothelium-dependent relaxation

Griffith, Tudor M., Edwards, David Hughes, Lewis, Malcolm J. and Henderson, Andrew H. 1985. Evidence that cyclic guanosine monophosphate (cGMP) mediates endothelium-dependent relaxation. European Journal of Pharmacology 112 (2) , pp. 195-202. 10.1016/0014-2999(85)90496-0

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The mechanism of action of endothelium-derived relaxant factor (EDRF) was studied using aortic strip preparations of the rabbit and a bioassay system of a rabbit coronary artery perfused in series with an intact aorta. Methylene blue (an inhibitor of guanylate cyclase) inhibited, and 2-O-propoxyphenyl-8-azapurine-6-one (MB22948, an inhibitor of cGMP phosphodiesterase) potentiated the vascular effects of EDRF whether these were due to its basal or to stimulated release. Infusion of these agents at different sites in the bioassay indicated that they act pharmacologically at the smooth muscle level and not on release of EDRF or by chemical interaction with EDRF. The data are consistent with the hypothesis that EDRF-induced relaxation is mediated by elevation of smooth muscle cGMP levels.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Endothelium-derived relaxant factor; Cyclic guanosine monophosphate (cGMP); Methylene blue; Vasodilatation; MB22948
Publisher: Elsevier
ISSN: 0014-2999
Last Modified: 04 Jun 2017 08:03

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