Pretherapeutic dosimetry in patients affected by metastatic thyroid cancer using I-124 PET/CT sequential scans for I-131 treatment planning

Pettinato, Cinzia, Spezi, Emiliano ORCID: https://orcid.org/0000-0002-1452-8813, Nanni, Cristina, Grassetto, Gaia, Monari, Fabio, Allegri, Vincenzo, Civollani, Simona, Cima, Simona, Zagni, Paolo, Mazzarotto, Renzo, Colletti, Patrick M., Rubello, Domenico and Fanti, Stefano 2014. Pretherapeutic dosimetry in patients affected by metastatic thyroid cancer using I-124 PET/CT sequential scans for I-131 treatment planning. Clinical Nuclear Medicine 39 (8) , E367-E374. 10.1097/RLU.0000000000000490

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Abstract

Purpose: This study evaluates the use of sequential 124I PET/CT for predicting absorbed doses to metastatic lesions in patients with differentiated thyroid cancer undergoing 131I therapy. Methods: From July 2011 until July 2013, 30 patients with metastatic differentiated thyroid cancer were enrolled. Each participant underwent PET/CT at 4, 24, 48, and 72 hours with 74 MBq of 124I. Blood samples and whole-body exposure measurements were obtained to calculate blood and red marrow doses. Activity concentrations and lesion volumes obtained from PET/CT were used to evaluate tumor doses with medical internal radiation dose formalism and spheres modeling. Mean administered 131I therapeutic dose was 5994 MBq (range, 1953–11,455 MBq). Results: 124I PET/CT demonstrated all lesions detected by posttherapy 131I whole-body scans. Mean dose rates for blood, red marrow, and lesions were as follows: 0.07 ± 0.02 mGy/MBq, 0.05 ± 0.02 mGy/MBq, and 46.5 ± 117 mGy/MBq, respectively. Despite the high level of thyroid-stimulating hormone and CT detectable lesions, 15 of 30 patients did not show any abnormal 124I uptake. Conclusions: The quantitative value of 124I PET/CT allows simple and accurate evaluation of lesion dosimetry following medical internal radiation dose formalism. Negative 124I PET/CT predicts absence of iodine avidity, potentially allowing avoidance of therapeutically ineffective 131I administration.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Engineering
Publisher:	Lippincott, Williams & Wilkins
ISSN:	0363-9762
Last Modified:	28 Oct 2022 08:53
URI:	https://orca.cardiff.ac.uk/id/eprint/72525

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