Can specific calcium channel blockade be the basis for a drug-based treatment of acute pancreatitis?

Petersen, Ole Holger ORCID: https://orcid.org/0000-0002-6998-0380 2014. Can specific calcium channel blockade be the basis for a drug-based treatment of acute pancreatitis? Expert Review of Gastroenterology & Hepatology 8 (4) , pp. 339-341. 10.1586/17474124.2014.896192

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Abstract

Acute pancreatitis is an inflammatory disease with a significant mortality, triggered by autodigestion and cell death. There is currently no specific treatment. Excessive intracellular Ca2+ signals, elicited by combinations of fat and alcohol or bile acids, initiate the intracellular protease activation that causes autodigestion. These abnormal Ca2+ signals are generated by excessive Ca2+ release from internal stores followed by excessive Ca2+ influx from the interstitial fluid. The intracellular protease activation is totally dependent on sustained Ca2+ influx. It has recently been shown that the influx pathway belongs to the CRAC (Ca2+ release activated Ca2+) channel type. A selective blocker is now available for this channel and recent work, reviewed in this editorial, shows that pharmacological blockade in isolated pancreatic acinar cells, prevents the excessive Ca2+ signal generation, intracellular protease activation and necrosis that is the root cause of acute pancreatitis. This gives hope for a rational treatment of this disease.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Biosciences Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Publisher:	Informa Healthcare
ISSN:	1747-4124
Last Modified:	28 Oct 2022 08:55
URI:	https://orca.cardiff.ac.uk/id/eprint/72622

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