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ADHD severity is associated with white matter microstructure in the subgenual cingulum

Cooper, Miriam ORCID: https://orcid.org/0000-0002-4695-5481, Thapar, Anita ORCID: https://orcid.org/0000-0002-3689-737X and Jones, Derek K. ORCID: https://orcid.org/0000-0003-4409-8049 2015. ADHD severity is associated with white matter microstructure in the subgenual cingulum. NeuroImage: Clinical 7 , pp. 653-660. 10.1016/j.nicl.2015.02.012

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Abstract

This analysis examined hypothesised associations between microstructural attributes in specific white matter (WM) tracts selected a priori and measures of clinical variability in adolescents with a diagnosis of attention deficit hyperactivity disorder (ADHD). Firstly, associations were explored between WM microstructure and ADHD severity in the subgenual cingulum. Secondly, to ensure that tract-specific approaches afforded enhanced rather than differential sensitivity, associations were measured between WM microstructure and autistic traits in the right corticospinal tract based on results of a previously-published voxelwise analysis.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Cardiff University Brain Research Imaging Centre (CUBRIC)
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Attention deficit hyperactivity disorder (ADHD); Autism spectrum disorder (ASD); Diffusion MRI; White matter; Spherical deconvolution; Tractography
Publisher: Elsevier
ISSN: 2213-1582
Funders: Wellcome Trust
Date of First Compliant Deposit: 30 March 2016
Date of Acceptance: 22 February 2015
Last Modified: 28 Oct 2022 09:00
URI: https://orca.cardiff.ac.uk/id/eprint/72922

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