Hiscox, Stephen Edward ORCID: https://orcid.org/0000-0003-0105-2702, Hallett, Maurice Bartlett ORCID: https://orcid.org/0000-0001-8197-834X, Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111, Puntis, Malcolm C. A. and Nakamura, Toshikazu 1997. Expression of the HGF/SF Receptor, c-met, and its ligand in human colorectal cancers. Cancer Investigation 15 (6) , pp. 513-521. 10.3109/07357909709047592 |
Abstract
The c-met proto-oncogene product is a receptor tyrosine kinase that mediates the effects of the multifunctional cytokine hepatocyte growth factor/scatter factor (HGF/SF). We have studied the expression of both the c-met receptor and HGF/SF at both the protein and message level in colorectal cancer tissues of varying disease stage. All of the tumors displayed an overexpression of the c-met mRNA compared to their normal tissue counterparts while 16 of 21 tissues (75%) displayed up-regulation of c-met protein. No HGF/SF mRNA or protein could be detected in either tissue type. Viable tumor cells extracted from cancer tissue exhibited increased motility in response to HGF/SF stimulation demonstrating that c-met was functionally active. No correlation between expression of c-met and tumor stage or degree of differentiation was observed. HGF/SF is known to be a potent stimulator of tumor cell motility and invasion, two cellular properties essential for the metastatic development of cancers. The overexpression of the HGF/SF receptor in colorectal cancers may result in an increased sensitivity to HGF/SF, which may confer an enhanced metastatic potential to the cancer cells within the tumor body.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine |
Subjects: | R Medicine > R Medicine (General) |
Publisher: | Informa Healthcare |
ISSN: | 0735-7907 |
Last Modified: | 28 Oct 2022 09:03 |
URI: | https://orca.cardiff.ac.uk/id/eprint/73136 |
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