Inhibition of neutrophil respiratory burst and cytokine priming by γ-linolenic acid

Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111, Puntis, M. C. A., Horrobin, D. F., Scott, C. and Hallett, Maurice Bartlett ORCID: https://orcid.org/0000-0001-8197-834X 1996. Inhibition of neutrophil respiratory burst and cytokine priming by γ-linolenic acid. British Journal of Surgery 83 (5) , pp. 659-664. 10.1002/bjs.1800830523

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Abstract

The effect of n-6 fatty acids, particularly y-linolenic acid (GLA), on the oxidase response and neutrophil priming by tumour necrosis factor a and interleukin 8 was studied in both normal volunteers and patients with obstructive jaundice. GLA inhibited the neutrophil respiratory burst at concentrations higher than 50 μmol/l, but abolished cytokine priming at concentrations as low as 1 μmmol/1. Inhibition was not the result of either cytotoxicity to the neutrophils or alteration in cytosolic free calcium homoeostasis. It is concluded that GLA is a potential inhibitor of neutrophil priming by cytokines and of the oxidative response.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Wiley-Blackwell
ISSN:	0007-1323
Last Modified:	28 Oct 2022 09:04
URI:	https://orca.cardiff.ac.uk/id/eprint/73140

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