Beta-adrenergic mobilization of Ca2+ from an intracellular store in rat submandibular acini

Mills, L., Hallett, Maurice Bartlett ORCID: https://orcid.org/0000-0001-8197-834X, McPherson, M. A. and Dormer, R. L. 1993. Beta-adrenergic mobilization of Ca2+ from an intracellular store in rat submandibular acini. Biochemical Journal 293 (3) , pp. 691-695.

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Abstract

Increases in cytoplasmic free Ca2+ concentration in rat submandibular acini were observed in response to isoprenaline (10 microM), noradrenaline (10 microM) and carbamoylcholine (10 microM). Noradrenaline and carbamoylcholine responses were decreased to 27% and 33% respectively in the absence of extracellular Ca2+, suggesting a major requirement for Ca2+ entry. beta-Adrenergic stimulation elicited a small (35-40 nM) free Ca2+ rise, approx. 75% of which was mobilized from an intracellular store. Results suggest that this Ca2+ rise is a key event in the physiological triggering of mucin secretion by exocytosis

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Biochemical Society
ISSN:	0264-6021
Last Modified:	28 Oct 2022 09:04
URI:	https://orca.cardiff.ac.uk/id/eprint/73173

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