Petersen, M., Williams, J. D. and Hallett, Maurice Bartkett  ORCID: https://orcid.org/0000-0001-8197-834X
1993.
Cross-linking of CD11b or CD18 signals release of localized Ca2+ from intracellular stores in neutrophils.
Immunology
80
(1)
, pp. 157-159.
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Abstract
Cross-linking of antibodies bound to CD11b or CD18 on the neutrophil surface produced a large Ca2+ transient (max. approximately 500 nM). The major source for this Ca2+ rise (more than 81%) was from an intracellular Ca2+ store. After integrin cross-linking, the Ca2+ transient induced by N-formyl-methionyl-leucyl-phenylalanine (FMLP) was decreased, suggesting that both stimuli acted on the same Ca2+ store. Release from the Ca2+ store, induced by integrin cross-linking, was visualized as a 'cloud' of elevated Ca2+, which remained localized even in the presence of extracellular Ca2+. The generation of localized cytosolic Ca2+ signals by cross-linking integrin may be important for triggering localized cellular responses
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine |
| Subjects: | R Medicine > R Medicine (General) |
| Publisher: | Wiley Blackwell |
| ISSN: | 0019-2805 |
| Related URLs: | |
| Last Modified: | 28 Oct 2022 09:04 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/73183 |
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