Neutrophil priming by hepatocyte growth factor, a novel cytokine

Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111, Puntis, M. C., Nakamura, T. and Hallett, Maurice Bartlett ORCID: https://orcid.org/0000-0001-8197-834X 1992. Neutrophil priming by hepatocyte growth factor, a novel cytokine. Immunology 77 (1) , pp. 147-149.

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Abstract

We demonstrate here that the recently defined cytokine hepatocyte growth factor (HGF) 'primes' human neutrophils. Recombinant human HGF over the concentration range 0.1-20 ng/ml increased the neutrophil response to f-met-leu-phe by up to 200%, and required only a short preincubation, 10 min producing the maximum effect. Priming was independent of changes in cytosolic-free calcium homeostasis. We conclude that HGF may be a physiologically important cytokine with 'priming' activity for neutrophils

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Wiley Blackwell
ISSN:	0019-2805
Related URLs:	http://www.ncbi.nlm.nih.gov/entrez/query...
Last Modified:	28 Oct 2022 09:04
URI:	https://orca.cardiff.ac.uk/id/eprint/73184

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