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Neutrophil priming by hepatocyte growth factor, a novel cytokine

Jiang, Wen Guo ORCID:, Puntis, M. C., Nakamura, T. and Hallett, Maurice Bartlett ORCID: 1992. Neutrophil priming by hepatocyte growth factor, a novel cytokine. Immunology 77 (1) , pp. 147-149.

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We demonstrate here that the recently defined cytokine hepatocyte growth factor (HGF) 'primes' human neutrophils. Recombinant human HGF over the concentration range 0.1-20 ng/ml increased the neutrophil response to f-met-leu-phe by up to 200%, and required only a short preincubation, 10 min producing the maximum effect. Priming was independent of changes in cytosolic-free calcium homeostasis. We conclude that HGF may be a physiologically important cytokine with 'priming' activity for neutrophils

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Wiley Blackwell
ISSN: 0019-2805
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Last Modified: 28 Oct 2022 09:04

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