Newland, Benjamin ORCID: https://orcid.org/0000-0002-5214-2604, Newland, Heike, Werner, Carsten, Rosser, Anne Elizabeth ORCID: https://orcid.org/0000-0002-4716-4753 and Wang, Wenxian 2015. Prospects for polymer therapeutics in Parkinson's disease and other neurodegenerative disorders. Progress in Polymer Science 44 , pp. 79-112. 10.1016/j.progpolymsci.2014.12.002 |
Preview |
PDF
- Accepted Post-Print Version
Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (2MB) | Preview |
Abstract
Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons and represents a growing health burden to western societies. Like many neurodegenerative disorders the cause is unknown, however, as the pathogenesis becomes ever more elucidated, it is becoming clear that effective delivery is a key issue for new therapeutics. The versatility of today's polymerization techniques allows the synthesis of a wide range of polymer materials which hold great potential to aid in the delivery of small molecules, proteins, genetic material or cells. In this review, we capture the recent advances in polymer based therapeutics of the central nervous system (CNS). We place the advances in historical context and, furthermore, provide future prospects in line with newly discovered advancements in the understanding of PD and other neurodegenerative disorders. This review provides researchers in the field of polymer chemistry and materials science an up-to-date understanding of the requirements placed upon materials designed for use in the CNS aiding the focus of polymer therapeutic design.
Item Type: | Article |
---|---|
Date Type: | Publication |
Status: | Published |
Schools: | Biosciences MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI) Pharmacy |
Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine > RM Therapeutics. Pharmacology |
Uncontrolled Keywords: | Controlled release; Growth factors; Gene delivery; Transfection; Cell therapies; Drug delivery |
Publisher: | Elsevier |
ISSN: | 0079-6700 |
Date of First Compliant Deposit: | 31 October 2017 |
Date of Acceptance: | 16 December 2014 |
Last Modified: | 14 Feb 2024 19:31 |
URI: | https://orca.cardiff.ac.uk/id/eprint/73255 |
Citation Data
Cited 28 times in Scopus. View in Scopus. Powered By Scopus® Data
Actions (repository staff only)
Edit Item |