Molecular analysis of carbohydrate−antibody interactions: case study using a bacillus anthracis tetrasaccharide

Oberli, Matthias A., Tamborrini, Marco, Tsai, Yu-Hsuan ORCID: https://orcid.org/0000-0003-0589-5088, Werz, Daniel B., Horlacher, Tim, Adibekian, Alexander, Gauss, Dominik, Mo?ller, Heiko M., Pluschke, Gerd and Seeberger, Peter H. 2010. Molecular analysis of carbohydrate−antibody interactions: case study using a bacillus anthracis tetrasaccharide. Journal of the American Chemical Society 132 (30) , pp. 10239-10241. 10.1021/ja104027w

Full text not available from this repository.

Abstract

The process for selecting potent and effective carbohydrate antigens is not well-established. A combination of synthetic glycan microarray screening, surface plasmon resonance analysis, and saturation transfer difference NMR spectroscopy was used to dissect the antibody-binding surface of a carbohydrate antigen, revealing crucial binding elements with atomic-level detail. This analysis takes the first step toward uncovering the rules for structure-based design of carbohydrate antigens.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Subjects:	Q Science > QD Chemistry
Publisher:	American Chemical Society
ISSN:	0002-7863
Last Modified:	04 Mar 2023 02:45
URI:	https://orca.cardiff.ac.uk/id/eprint/73728

Citation Data

Cited 63 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item