Touchet, Sabrina, Chamberlain, Keith, Woodcock, Christine M., Miller, David J., Birkett, Michael A., Pickett, John A. ![]() ![]() ![]() |
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Official URL: http://dx.doi.org/10.1039/C5CC01814E
Abstract
A synthetic biology approach to the rational design of analogues of olfactory ligands by providing unnatural substrates for the enzyme synthesising (S)-germacrene D, an olfactory ligand acting as a plant derived insect repellent, to produce novel ligands is described as a viable alternative to largely unsuccessful ligand docking studies. (S)-14,15-Dimethylgermacrene D shows an unexpected reversal in behavioural activity.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Chemistry |
Subjects: | Q Science > QD Chemistry |
Publisher: | Royal Society of Chemistry |
ISSN: | 1359-7345 |
Funders: | BBSRC |
Date of First Compliant Deposit: | 30 March 2016 |
Date of Acceptance: | 30 March 2015 |
Last Modified: | 06 May 2023 02:31 |
URI: | https://orca.cardiff.ac.uk/id/eprint/73825 |
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