Novel olfactory ligands via terpene synthases

Touchet, Sabrina, Chamberlain, Keith, Woodcock, Christine M., Miller, David J., Birkett, Michael A., Pickett, John A. ORCID: https://orcid.org/0000-0002-1008-6595 and Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 2015. Novel olfactory ligands via terpene synthases. Chemical Communications 51 (35) , pp. 7550-7553. 10.1039/C5CC01814E

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Abstract

A synthetic biology approach to the rational design of analogues of olfactory ligands by providing unnatural substrates for the enzyme synthesising (S)-germacrene D, an olfactory ligand acting as a plant derived insect repellent, to produce novel ligands is described as a viable alternative to largely unsuccessful ligand docking studies. (S)-14,15-Dimethylgermacrene D shows an unexpected reversal in behavioural activity.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Subjects:	Q Science > QD Chemistry
Publisher:	Royal Society of Chemistry
ISSN:	1359-7345
Funders:	BBSRC
Date of First Compliant Deposit:	30 March 2016
Date of Acceptance:	30 March 2015
Last Modified:	06 May 2023 02:31
URI:	https://orca.cardiff.ac.uk/id/eprint/73825

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