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Novel olfactory ligands via terpene synthases

Touchet, Sabrina, Chamberlain, Keith, Woodcock, Christine M., Miller, David J., Birkett, Michael A., Pickett, John A. ORCID: and Allemann, Rudolf K. ORCID: 2015. Novel olfactory ligands via terpene synthases. Chemical Communications 51 (35) , pp. 7550-7553. 10.1039/C5CC01814E

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A synthetic biology approach to the rational design of analogues of olfactory ligands by providing unnatural substrates for the enzyme synthesising (S)-germacrene D, an olfactory ligand acting as a plant derived insect repellent, to produce novel ligands is described as a viable alternative to largely unsuccessful ligand docking studies. (S)-14,15-Dimethylgermacrene D shows an unexpected reversal in behavioural activity.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Publisher: Royal Society of Chemistry
ISSN: 1359-7345
Funders: BBSRC
Date of First Compliant Deposit: 30 March 2016
Date of Acceptance: 30 March 2015
Last Modified: 06 May 2023 02:31

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