Beaufort, Nathalie, Scharrer, Eva, Lux, Vanda, Ehrmann, Michael ![]() |
Official URL: http://dx.doi.org/10.1073/pnas.1501817112
Abstract
We thank Liu et al. (1) for their comments on our work on the link between the cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL)-related protease high temperature requirement protein A1 (HtrA1) and the TGF-β signaling pathway. To advance our understanding of the mechanisms underlying HtrA1 deficiency, we used dermal fibroblasts from CARASIL patients and Htra1 knockout mice as experimental systems (2). We agree with Liu et al. that findings from fibroblasts might or might not fully reflect the physiological processes occurring in a vessel wall and that alterations in other cell types …
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Biosciences |
Subjects: | Q Science > QR Microbiology |
Publisher: | National Academy of Sciences |
ISSN: | 0027-8424 |
Last Modified: | 28 Oct 2022 09:19 |
URI: | https://orca.cardiff.ac.uk/id/eprint/74144 |
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