IL-21 induces the expression of markers associated with follicular B cell help by human gamma delta T cells [Abstract]

Bansal, R. R., Mackay, C. R., Moser, Bernhard ORCID: https://orcid.org/0000-0002-4354-4572 and Eberl, Matthias 2010. IL-21 induces the expression of markers associated with follicular B cell help by human gamma delta T cells [Abstract]. Immunology 131 (s1) , p. 38. 10.1111/j.1365-2567.2010.03389.x

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Abstract

Vγ9/Vδ2 T cells are a minor subset of T cells in human blood and differ from all other lymphocytes by their specific responsiveness to (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP), a metabolite produced by a large range of microbial pathogens. Vγ9/Vδ2 T cells can be skewed towards distinct effector functions, in analogy to, and beyond, the emerging plasticity of CD4+ T cells. As such, depending on the microenvironment, Vγ9/Vδ2 T cells can assume features reminiscent of Th1, Th2, Th17 and Treg cells as well as professional APCs. We here demonstrate that Vγ9/Vδ2 T cells express markers associated with follicular B helper T (TFH) cells when stimulated with HMB-PP in the presence of IL-21. HMB-PP induces upregulation of IL-21R on Vγ9/Vδ2 T cells. In return, IL-21 plays a co-stimulatory role in the expression of the B-cell-attracting chemokine CXCL13, the CXCL13 receptor CXCR5 and the inducible co-stimulator by activated Vγ9/Vδ2 T cells, and enhances their potential to support antibody production by B cells. The interaction between HMB-PP-responsive Vγ9/Vδ2 T cells, IL-21-producing TFH cells and B cells in secondary lymphoid tissues is likely to impact on the generation of high affinity, class-switched antibodies in microbial infections.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine Research Institutes & Centres > Systems Immunity Research Institute (SIURI)
Subjects:	Q Science > QR Microbiology > QR180 Immunology
Uncontrolled Keywords:	Bacterial infections; B cells; γδ T cells; IL-21; TFH cells
Publisher:	Wiley-Blackwell
Last Modified:	28 Oct 2022 09:20
URI:	https://orca.cardiff.ac.uk/id/eprint/74182

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