Volatile fluorinated nanoemulsions: a chemical route to controlled delivery of inhalation anesthesia

Salama, Ibrahim E., Jenkins, Claire L., Davies, Alun, Clark, Jeffrey N., Wilkes, Antony R., Hall, Judith E. ORCID: https://orcid.org/0000-0002-6770-7372 and Paul, Alison ORCID: https://orcid.org/0000-0002-7653-9964 2015. Volatile fluorinated nanoemulsions: a chemical route to controlled delivery of inhalation anesthesia. Journal of Colloid and Interface Science 440 , pp. 78-83. 10.1016/j.jcis.2014.10.021

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Abstract

Novel dispersions of the volatile inhalation anesthetic sevoflurane have been formulated that can provide controlled, sustainable release of anesthetic over clinically useful timescales. The emulsions can be simply formed with manual shaking, reproducibly yielding droplets of the order of 250 nm diameter, i.e. within the nanoemulsion range. Using a custom flow-rig, release of anesthetic gas from the emulsion has been evaluated, and clinically useful levels achieved through appropriate stirring of the formulation. Stirring can also be used to temporarily increase or decrease the amount of anesthetic released. Once consideration of the unusual nature of the fluorinated systems (phase separation by sedimentation rather than creaming), and the highly perturbed environment of their evaluation (under stirring and flow of gas), the observed behavior regarding sevoflurane evaporation can be reasonably well explained by existing theoretical models. Links between anesthetic release and emulsion structure have been defined, providing the basis for future development.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry Medicine
Subjects:	Q Science > QD Chemistry R Medicine > R Medicine (General)
Uncontrolled Keywords:	Anesthesia; Drug-delivery; Nanoemulsions; Fluorocarbon; Nanotechnology
Publisher:	Elsevier
ISSN:	0021-9797
Date of Acceptance:	16 October 2014
Last Modified:	28 Oct 2022 09:24
URI:	https://orca.cardiff.ac.uk/id/eprint/74404

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