Nestin regulates prostate cancer cell invasion by influencing the localisation and functions of FAK and integrins

Hyder, C. L., Lazaro, Glorianne, Pylvanainen, J. W., Roberts, M. W. G., Qvarnstrom, S. M. and Eriksson, J. E. 2014. Nestin regulates prostate cancer cell invasion by influencing the localisation and functions of FAK and integrins. Journal of Cell Science 127 (10) , pp. 2161-2173. 10.1242/jcs.125062

Full text not available from this repository.

Abstract

Nestin, an intermediate filament protein and marker of undifferentiated cells, is expressed in several cancers. Nestin is important for neuronal survival and is a regulator of myogenesis but its function in malignancy is ambiguous. We show that nestin downregulation leads to a redistribution of phosphorylated focal adhesion kinase (pFAK, also known as PTK2) to focal adhesions and alterations in focal adhesion turnover. Nestin downregulation also leads to an increase in the protein levels of integrin α5β1 at the cell membrane, activation of integrin β1 and an increase in integrin clustering. These effects have striking consequences for cell invasion, as nestin downregulation leads to a significant increase in pFAK- and integrin-dependent matrix degradation and cell invasion. Our results indicate that nestin regulates the localisation and functions of FAK and integrin. Because nestin has been shown to be prevalent in a number of specific cancers, our observations have broad ramifications for the roles of nestin in malignant transformation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	The Company of Biologists Ltd
ISSN:	0021-9533
Last Modified:	21 Feb 2019 15:38
URI:	https://orca.cardiff.ac.uk/id/eprint/74487

Citation Data

Cited 38 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item