Novel bicyclic furanopyrimidines with dual anti-VZV and -HCMV activity

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Andrei, Graciela, Snoeck, Robert, De Clercq, Erik and Balzarini, Jan 2003. Novel bicyclic furanopyrimidines with dual anti-VZV and -HCMV activity. Bioorganic & Medicinal Chemistry Letters 13 (24) , pp. 4511-4513. 10.1016/j.bmcl.2003.08.028

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Abstract

Several novel bicyclic furanopyrimidine deoxy nucleosides have been designed, prepared and evaluated as anti-Varicella Zoster Virus agents. The compounds have long ether side chains. Uniquely amongst compounds of this family to date the present agents show dual anti- (VZV) and human cytomegalovirus (HCMV) activity. The lead compounds inhibit VZV at 10 nM and HCMV at 5 μM.

Item Type:	Article
Status:	Published
Schools:	Pharmacy Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica
ISSN:	0960-894X
Last Modified:	05 Jan 2024 05:59
URI:	https://orca.cardiff.ac.uk/id/eprint/7488

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