Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Novel bicyclic furanopyrimidines with dual anti-VZV and -HCMV activity

McGuigan, Christopher ORCID:, Brancale, Andrea ORCID:, Andrei, Graciela, Snoeck, Robert, De Clercq, Erik and Balzarini, Jan 2003. Novel bicyclic furanopyrimidines with dual anti-VZV and -HCMV activity. Bioorganic & Medicinal Chemistry Letters 13 (24) , pp. 4511-4513. 10.1016/j.bmcl.2003.08.028

Full text not available from this repository.


Several novel bicyclic furanopyrimidine deoxy nucleosides have been designed, prepared and evaluated as anti-Varicella Zoster Virus agents. The compounds have long ether side chains. Uniquely amongst compounds of this family to date the present agents show dual anti- (VZV) and human cytomegalovirus (HCMV) activity. The lead compounds inhibit VZV at 10 nM and HCMV at 5 μM.

Item Type: Article
Status: Published
Schools: Pharmacy
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > R Medicine (General)
R Medicine > RS Pharmacy and materia medica
ISSN: 0960-894X
Last Modified: 17 Oct 2022 10:15

Citation Data

Cited 13 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item