COMT Val158Met genotype is associated with fluctuations in working memory performance: converging evidence from behavioural and single-trial P3b measures

Saville, C. W. N., Lancaster, Thomas ORCID: https://orcid.org/0000-0003-1322-2449, Stefanou, M. E., Salunkhe, G., Lourmpa, I., Nadkarni, A., Boehm, S. G., Bender, S., Smyrnis, N., Ettinger, U., Feige, B., Biscaldi, M., Mantripragada, Kiran Kumar ORCID: https://orcid.org/0000-0003-2070-8105, Linden, David Edmund Johannes ORCID: https://orcid.org/0000-0002-5638-9292 and Klein, C. 2014. COMT Val158Met genotype is associated with fluctuations in working memory performance: converging evidence from behavioural and single-trial P3b measures. NeuroImage 100 , pp. 489-497. 10.1016/j.neuroimage.2014.06.006

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Abstract

Intra-subject variability in reaction times (ISV) is a promising endophenotype for several psychiatric conditions, but its neural underpinnings are not yet established. Converging evidence from neuroimaging, molecular genetics, and psychopharmacology suggests that ISV could index catecholaminergically-mediated neural noise. The fine-grained temporal resolution of electroencephalography is ideal for investigating ISV, but only if potential neural correlates of ISV can be assessed in single trials. Based on evidence that ISV is associated with dopaminergic functioning, we apply a recently developed method of single-trial P3b analysis to investigate the association of COMT Val(158)Met genotype with measures of ISV on the behavioural and neural levels at different working memory loads. Greater number of Met alleles was associated with poorer and more intra-individually variable performance on the tasks, and greater latency jitter in single-trial P3bs. These converging results at the behavioural and neurophysiological levels confirm previous observations that prefrontal dopamine availability is associated with stability and accuracy of cognitive performance. Together with previous studies, these data imply pleiotropic cognitive effects of COMT genotype.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	Endophenotype; Intra-subject variability; Reaction time variability; P300; rs4680; Mental chronometry
Publisher:	Elsevier
ISSN:	1053-8119
Date of Acceptance:	2 June 2014
Last Modified:	28 Oct 2022 09:33
URI:	https://orca.cardiff.ac.uk/id/eprint/74886

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