Brix, Maiken K., Ersland, Lars, Hugdahl, Kenneth, Grüner, Renate, Posserud, Maj-Britt, Hammar, Åsa, Craven, Alexander R., Noeske, Ralph, Evans, Christopher John  ORCID: https://orcid.org/0000-0002-6619-4245, Walker, Hanne B., Midtvedt, Tore and Beyer, Mona K.
2015.
Brain MR spectroscopy in autism spectrum disorder - the GABA excitatory/inhibitory imbalance theory revisited.
Frontiers in Human Neuroscience
9
, 00365.
10.3389/fnhum.2015.00365
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Abstract
Magnetic resonance spectroscopy (MRS) from voxels placed in the left anterior cingulate cortex (ACC) was measured from 14 boys with Autism Spectrum Disorder (ASD) and 24 gender and age-matched typically developing (TD) control group. Our main aims were to compare the concentration of γ-aminobutyric acid (GABA) between the two groups, and to investigate the relationship between brain metabolites and autism symptom severity in the ASD group. We did find a significant negative correlation in the ASD group between Autism Spectrum Screening Questionnaire (ASSQ) and GABA+/Cr, which may imply that severity of symptoms in ASD is associated with differences in the level of GABA in the brain, supporting the excitatory/inhibitory (E/I) imbalance theory. However we did not find a significant difference between the two groups in GABA levels.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Research Institutes & Centres > Cardiff University Brain Research Imaging Centre (CUBRIC) Schools > Psychology |
| Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| Additional Information: | This Document is protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission |
| Publisher: | Frontiers Research Foundation |
| ISSN: | 1662-5161 |
| Date of First Compliant Deposit: | 30 March 2016 |
| Date of Acceptance: | 8 June 2015 |
| Last Modified: | 06 May 2023 01:22 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/74987 |
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