Follow-up of loci from the International Genomics of Alzheimer's Disease Project identifies TRIP4 as a novel susceptibility gene

Ruiz, A., Heilmann, S., Becker, T., Hernández, I., Wagner, H., Thelen, M., Mauleón, A., Rosende-Roca, M., Bellenguez, C., Bis, J. C., Harold, D. ORCID: https://orcid.org/0000-0001-5195-0143, Gerrish, A., Sims, R. ORCID: https://orcid.org/0000-0002-3885-1199, Sotolongo-Grau, O., Espinosa, A., Alegret, M., Arrieta, J. L., Lacour, A., Leber, M., Becker, J., Lafuente, A., Ruiz, S., Vargas, L., Rodríguez, O., Ortega, G., Dominguez, M.-A., Mayeux, R., Haines, J. L., Pericak-Vance, M. A., Farrer, L. A., Schellenberg, G. D., Chouraki, V., Launer, L.J., van Duijn, C., Seshadri, S., Antúnez, C., Breteler, M. M., Serrano-Ríos, M., Jessen, F., Tárraga, L., Nöthen, M. M., Maier, W., Boada, M., Ramírez, A. and Williams, J. ORCID: https://orcid.org/0000-0002-4069-0259 2014. Follow-up of loci from the International Genomics of Alzheimer's Disease Project identifies TRIP4 as a novel susceptibility gene. Translational Psychiatry 4 , e358. 10.1038/tp.2014.2

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Abstract

To follow-up loci discovered by the International Genomics of Alzheimer's Disease Project, we attempted independent replication of 19 single nucleotide polymorphisms (SNPs) in a large Spanish sample (Fundació ACE data set; 1808 patients and 2564 controls). Our results corroborate association with four SNPs located in the genes INPP5D, MEF2C, ZCWPW1 and FERMT2, respectively. Of these, ZCWPW1 was the only SNP to withstand correction for multiple testing (P=0.000655). Furthermore, we identify TRIP4 (rs74615166) as a novel genome-wide significant locus for Alzheimer's disease risk (odds ratio=1.31; confidence interval 95% (1.19-1.44); P=9.74 × 10(-)(9)).

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects:	R Medicine > R Medicine (General)
Additional Information:	This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License Julie Williams is part of the GERAD research group, which is part of the IGAP consortium
Publisher:	Springer Nature
ISSN:	2158-3188
Date of First Compliant Deposit:	12 June 2020
Date of Acceptance:	6 January 2014
Last Modified:	25 Oct 2024 01:20
URI:	https://orca.cardiff.ac.uk/id/eprint/75186

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