Current state of mTOR targeting in human breast cancer

Wazir, Umar, Wazir, Ali, Khanzada, Zubair S., Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111, Sharma, Anup K. and Mokbel, Kefah 2014. Current state of mTOR targeting in human breast cancer. Cancer Genomics and Proteomics 11 (4) , pp. 167-174.

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Abstract

Background/Aim: The mammalian, or mechanistic, target of rapamycin (mTOR) pathway has been implicated in several models of human oncogenesis. Research in the role of mTOR in human oncogenesis remains a field of intense activity. In this mini-review, we intend to recount our current understanding of the mTOR pathway, its interactions, and its role in human carcinogenesis in general, and breast cancer in particular. Materials and Methods: We herein outline the discrete components of the two complexes of mTOR, and attempt to define their distinct roles and interactions. Furthermore, we review current developments in the therapeutic targeting of mTOR in human breast cancer. Results: Our understanding of the organisation and interactions of the mTOR pathway continues to evolve. There has been significant incremental, albeit slow, progress in the therapeutic targeting of the mTOR pathway in human breast cancer. Conclusion: Continued progress in the field would require a better understanding of the role of the mTOR pathway in human breast cancer. By summarizing the current literature, this review will provide useful information on the topic.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	International Institute of Anticancer Research
ISSN:	1109-6535
Date of Acceptance:	9 June 2014
Last Modified:	28 Oct 2022 09:48
URI:	https://orca.cardiff.ac.uk/id/eprint/75791

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