Regulation of motility and invasion of cancer cells by human monocytic cells

Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111, Hiscox, S., Hallett, Maurice Bartlett ORCID: https://orcid.org/0000-0001-8197-834X, Mansel, R E. and Puntis, M. C. 1995. Regulation of motility and invasion of cancer cells by human monocytic cells. Anticancer Research 15 (4) , pp. 1303-1310.

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Abstract

Tumour tissues are frequently seen with monocyte/macrophage infiltration. This study was to establish the role of monocytes on the motile and invasive behaviour of human cancer cells. By using a co-culture technique, we have shown that both human peripheral blood monocytes and a monocytic cell line, U937, stimulated colon and breast cancer cell colony scattering, motility, and invasion into a basement membrane (Matrigel). This effect was enhanced when monocytic cells were stimulated by a particulate stimulus. IL-4 and IL-10 reduced these effects of monocytes. We conclude that monocytic cells enhance the motility and invasion of tumour cells. These effects can be regulated by inhibitory cytokines of monocytes.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	Cell Division, Cell Movement, Humans, Interleukin-10/pharmacology, Interleukin-4/pharmacology, Monocytes/physiology*, Neoplasm Invasiveness*, Tumor Cells, Cultured
Publisher:	International Institute of Anticancer Research
ISSN:	0250-7005
Last Modified:	28 Oct 2022 09:51
URI:	https://orca.cardiff.ac.uk/id/eprint/75897

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