Jiang, Wen Guo  ORCID: https://orcid.org/0000-0002-3283-1111, Hiscox, S., Hallett, Maurice Bartlett ORCID: https://orcid.org/0000-0001-8197-834X, Mansel, R E. and Puntis, M. C.
1995.
Regulation of motility and invasion of cancer cells by human monocytic cells.
Anticancer Research
15
(4)
, pp. 1303-1310.
|
Abstract
Tumour tissues are frequently seen with monocyte/macrophage infiltration. This study was to establish the role of monocytes on the motile and invasive behaviour of human cancer cells. By using a co-culture technique, we have shown that both human peripheral blood monocytes and a monocytic cell line, U937, stimulated colon and breast cancer cell colony scattering, motility, and invasion into a basement membrane (Matrigel). This effect was enhanced when monocytic cells were stimulated by a particulate stimulus. IL-4 and IL-10 reduced these effects of monocytes. We conclude that monocytic cells enhance the motility and invasion of tumour cells. These effects can be regulated by inhibitory cytokines of monocytes.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine |
| Subjects: | R Medicine > R Medicine (General) |
| Uncontrolled Keywords: | Cell Division, Cell Movement, Humans, Interleukin-10/pharmacology, Interleukin-4/pharmacology, Monocytes/physiology*, Neoplasm Invasiveness*, Tumor Cells, Cultured |
| Publisher: | International Institute of Anticancer Research |
| ISSN: | 0250-7005 |
| Last Modified: | 28 Oct 2022 09:51 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/75897 |
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