Jiang, Wen Guo ![]() ![]() |
Abstract
Tumour tissues are frequently seen with monocyte/macrophage infiltration. This study was to establish the role of monocytes on the motile and invasive behaviour of human cancer cells. By using a co-culture technique, we have shown that both human peripheral blood monocytes and a monocytic cell line, U937, stimulated colon and breast cancer cell colony scattering, motility, and invasion into a basement membrane (Matrigel). This effect was enhanced when monocytic cells were stimulated by a particulate stimulus. IL-4 and IL-10 reduced these effects of monocytes. We conclude that monocytic cells enhance the motility and invasion of tumour cells. These effects can be regulated by inhibitory cytokines of monocytes.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine |
Subjects: | R Medicine > R Medicine (General) |
Uncontrolled Keywords: | Cell Division, Cell Movement, Humans, Interleukin-10/pharmacology, Interleukin-4/pharmacology, Monocytes/physiology*, Neoplasm Invasiveness*, Tumor Cells, Cultured |
Publisher: | International Institute of Anticancer Research |
ISSN: | 0250-7005 |
Last Modified: | 28 Oct 2022 09:51 |
URI: | https://orca.cardiff.ac.uk/id/eprint/75897 |
Citation Data
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