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Regulation of motility and invasion of cancer cells by human monocytic cells

Jiang, Wen Guo ORCID:, Hiscox, S., Hallett, Maurice Bartlett ORCID:, Mansel, R E. and Puntis, M. C. 1995. Regulation of motility and invasion of cancer cells by human monocytic cells. Anticancer Research 15 (4) , pp. 1303-1310.

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Tumour tissues are frequently seen with monocyte/macrophage infiltration. This study was to establish the role of monocytes on the motile and invasive behaviour of human cancer cells. By using a co-culture technique, we have shown that both human peripheral blood monocytes and a monocytic cell line, U937, stimulated colon and breast cancer cell colony scattering, motility, and invasion into a basement membrane (Matrigel). This effect was enhanced when monocytic cells were stimulated by a particulate stimulus. IL-4 and IL-10 reduced these effects of monocytes. We conclude that monocytic cells enhance the motility and invasion of tumour cells. These effects can be regulated by inhibitory cytokines of monocytes.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Cell Division, Cell Movement, Humans, Interleukin-10/pharmacology, Interleukin-4/pharmacology, Monocytes/physiology*, Neoplasm Invasiveness*, Tumor Cells, Cultured
Publisher: International Institute of Anticancer Research
ISSN: 0250-7005
Last Modified: 28 Oct 2022 09:51

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